Sodium dodecyl sulfate
Sodium dodecyl sulfate is white to pale yellow crystal or powder, soluble in water, almost insoluble in ether. It is an anionic surfactant with good solubilizing ability. It is composed of a variety of fatty alcohol sodium sulfonate, and the solubilization of different fatty acid sodium sulfonate is different. It is often used as a solubilizer, cosolvent, emulsifier and lubricant in pharmaceutical excipients.
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Sodium dodecyl sulfate
Detailed introduction
1. Product Description
Sodium dodecyl sulfate is white to pale yellow crystal or powder, soluble in water, almost insoluble in ether. It is an anionic surfactant with good solubilizing ability. It is composed of a variety of fatty alcohol sodium sulfonate, and the solubilization of different fatty acid sodium sulfonate is different. It is often used as a solubilizer, cosolvent, emulsifier and lubricant in pharmaceutical excipients.
|
Product Name |
English Name |
CAS No. |
Item No. |
Packing specification |
Executive standard |
CDE Registration Number |
FDA Registration Number |
|
Sodium dodecyl sulfate |
Sodium Lauryl Sulfate |
151-21-3 |
F310-020000 |
20 kg/bag |
CP/USP/EP/JP |
F20209990193(A) F20170000137(A) |
033606（A） |
2. Product advantages
Higher stability, better solubilization, more emulsification: through the purity of raw materials and process control, to maintain a stable composition of sodium fatty acid sulfonate, the total alcohol content of the product can reach more than 60%, so that the product has a stable solubilization and emulsification capacity;
Higher purity: Through a special refining process, the content of inorganic salts (sodium sulfate and sodium chloride) and unesterified alcohol is reduced, and the purity of sodium dodecyl sulfate is improved.
3. Product Application
Solvents, co-solventsSodium dodecyl sulfate has hydrophilic and hydrophobic groups in the molecule, and is often used as a solubilizer and cosolvent in pharmaceutical preparations. For example, sodium lauryl sulfate in aspirin can act as a solubilizer.
EmulsifierSodium lauryl sulfate is a commonly used emulsifier in emulsions and can be used to formulate oil-in-water emulsion bases. Often combined with other water-in-oil emulsifiers to adjust the HLB value of the cream system, the emulsifying effect is better.
LubricantSodium lauryl sulfate can be used as a lubricant in solid formulations and has the effect of improving in vitro dissolution in tablets. For example, sodium lauryl sulfate is used as a lubricant in celecoxib tablets.
bacteriostatic agentSodium dodecyl sulfate can disintegrate the cell membrane, bind to the hydrophobic part of the membrane protein and separate from the membrane. It has antibacterial effect on gram-positive bacteria and Staphylococcus aureus.
Other rolesIt is used as a skin cleanser in topical preparations and is widely used in tablet dissolution determination, etc.
4. Characteristic R & D service
1. National Pharmacopoeia Detection Operation Decomposition Guidance
2. Customized specialty preparation services
Key words:
sodium
sulfate
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