Crospovidone
Crosslinked povidone is a water-insoluble homopolymer of N-vinyl-2-pyrrolidone, which is a white or almost white powder and insoluble in water, ethanol or chloroform. Crosslinked povidone is suitable for various tabletting processes. It will expand rapidly when absorbing water, but it does not form gel. It has good fluidity and plasticity, and has high pressure. It is commonly used as a disintegrating agent and filler, and can also improve the solubility of insoluble drugs.
Classification:
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Crospovidone
Detailed introduction
1. Product Description
Crosslinked povidone is a water-insoluble homopolymer of N-vinyl-2-pyrrolidone, which is a white or almost white powder and insoluble in water, ethanol or chloroform. Crosslinked povidone is suitable for various tabletting processes. It will expand rapidly when absorbing water, but it does not form gel. It has good fluidity and plasticity, and has high pressure. It is commonly used as a disintegrating agent and filler, and can also improve the solubility of insoluble drugs.
|
Product Name |
English Name |
CAS No. |
Item No. |
Packing specification |
Executive standard |
CDE Registration Number |
FDA Registration Number |
|
crospovidone |
Crospovidone |
9003-39-8 |
F205-010000F205-020000 |
10kg/box 20kg/barrel |
CP/USP/EP/JP |
F20209990199(A) |
—— |
2. Product advantages
Stable supply: GMP conditions of production, fully domestic.
Meet the needs of different regulatory market standards: CP/USP/EP/JP.
Lower impurity residue: strictly control the residue of impurities and pollutants.
Customized packaging: different sizes of packaging can be used according to customer needs.
Higher safety: strict control of microorganisms and endotoxins.
3. Product Application
Disintegrant:Crospovidone can be used as a disintegrant for tablets, pills, granules and hard capsules, which will rapidly absorb water and swell. Cross-linked povidone can effectively improve drug dissolution and bioavailability, and can be used for wet granulation, dry granulation and direct powder compression.
Dissolution Accelerator:Crospovidone can improve the dissolution rate of insoluble drugs. For example, crospovidone can improve the dissolution rate of telmisartan, paracetamol, ganciclovir and other drugs.
4. Characteristic R & D service
1) National pharmacopoeia testing operation decomposition guidance
2) Customized specialty preparation services.
Key words:
crospovidone
insoluble
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