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Sulfobutyl betahistine cyclodextrin sodium

Sulfobutyl betacyclodextrin sodium is a polyanionic β-cyclodextrin derivative, which has the advantages of increasing drug solubility, improving drug stability and other functions and good safety. Can be used as a solubilizer, wetting agent, chelating agent and multi-valent masking agent, etc., has been applied to injection medicine, oral medicine, nasal medicine, eye medicine, for nitrogen-containing drugs have a special affinity.

Classification:

Other specialty medicinal excipients

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Sulfobutyl betahistine cyclodextrin sodium

Detailed introduction

1. Product Description

Product Name	English Name	CAS No.	Item No.	Packing specification	Executive standard	CDE Registration Number	FDA Registration Number
Sulfobutyl betahistine cyclodextrin sodium	Betadex Sulfobutyl Ether Sodium	182410-00-0	F243-000500	500g/bottle	USP/EP	F20180001671	——

2. Product advantages

Stable supply: GMP conditions of production, fully domestic.

Meet the needs of different regulatory market standards: USP/EP;

Lower impurity residue: strictly control the residue of impurities and pollutants;

Customized packaging: different sizes of packaging can be used according to customer needs;

Higher safety: strict control of microorganisms and endotoxins.

3. Product Application

Oral preparations:Sulfobutyl betacyclodextrin sodium can be used as an inclusion material to form an inclusion complex with insoluble drugs, thereby improving the solubility of insoluble drugs and increasing the bioavailability of oral drugs. For example, itraconazole, ketoprofen, danazol, etc.

Injection:Sulfobutyl betalic cyclodextrin sodium can reduce the irritation of the injection to the administration site, make the drug quickly reach the required blood concentration, and prolong the action time of the drug. For example, ziprasidone, fentanyl, amiodarone, etc.

nasal drug delivery preparations:Sulfobutyl betalic cyclodextrin sodium used in nasal delivery preparations, can improve the solubility and stability of the drug, increase the permeability of the nasal mucosa, is conducive to improving the bioavailability of the drug. Such as ondansetron, midazolam, etc.

Ophthalmologic preparations:The inclusion of sulfobutyl beta cyclodextrin sodium with irritant drugs can cover its irritation, increase the corneal transmittance of the drug, and improve the bioavailability. For example balofloxacin.

transdermal drug delivery preparations:The application of sulfobutyl betadextrin sodium in transdermal drug delivery preparations can increase the transdermal permeability of the drug, thereby improving the bioavailability, improving the solubility and stability of the drug, preventing the loss of volatile components, and masking the bad odor.

4. Characteristic R & D service

1) National pharmacopoeia testing operation decomposition guidance

2) Customized specialty preparation services.

Key words:

drug

medicine

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