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Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)

Disodium hydrogen phosphate is soluble in water, its aqueous solution is alkaline, insoluble in alcohol, white powder, flake or granular matter, easy to weathering in the air, when placed in the air at room temperature, it loses about 5 crystal water to form heptahydrate, when heated to 100 ℃, it loses all crystal water and becomes anhydrous, and when 250 ℃, it decomposes into sodium pyrophosphate.

Classification:

Pharmaceutical excipients for biologics

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Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)

Detailed introduction

1. Product Description

Product Name	English Name	CAS No.	Item No.	Packing specification	Executive standard	CDE Registration Number	FDA Registration Number
Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)	Disodium Hydrogen Phosphate	7558-79-4 10028-24-7 7782-85-6 10039-32-4		2.5kg/bottle	CP/USP/EP/JP	F20209990173(A)	——
Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)	Disodium Hydrogen Phosphate	7558-79-4 10028-24-7 7782-85-6 10039-32-4		10kg/barrel	CP/USP/EP/JP	F20209990173(A)	——
Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)	Disodium Hydrogen Phosphate	7558-79-4 10028-24-7 7782-85-6 10039-32-4		25kg/barrel	CP/USP/EP/JP	F20209990173(A)	——

2. Product advantages

Meet the needs of different regulatory market standards: CP/USP/EP/JP;

Lower impurity residue: strictly control the residue of impurities and pollutants;

Customized packaging: different sizes of packaging can be used according to customer needs;

Higher safety: strict control of microorganisms and endotoxins.

Product Name	English Name	endotoxin	Aerobic bacteria (TAMC)	Mold and Yeast (TYMC)	Escherichia coli
Disodium hydrogen phosphate (anhydrous/dihydrate/seven water/twelve water)	Disodium Hydrogen Phosphate	<2.0EU/g	<100cfu/g	<10cfu/g	None

3. Product Application

pH regulatorAs a buffer and chelating agent, disodium hydrogen phosphate is widely used in the field of pharmaceutical preparations, and the phosphate buffer system is the most widely used buffer system in biochemical research, which has the following advantages:

1) easy to prepare into various concentrations of buffer;

2) The applicable pH range is wide;

3)pH is little affected by temperature;

4) After buffer dilutionThe change of pH is small, such as the change of pH after ten times dilution is less than 0.1.

Treatment of hypophosphatemia:Disodium hydrogen phosphate is widely used as an excipient for injectable, oral and topical preparations. Phosphate is widely present in the body and is involved in many physiological processes because it is the main anion of intracellular fluid. Most foods contain a significant amount of phosphate, and the average person does not suffer from hypophosphatemia (phosphate deficiency), except in patients with certain diseases or receiving total nutritional infusions. Usually less than 100mmol of oral phosphate per day can be treated for this disease. Approximately two-thirds of the phosphate ingested is absorbed by the gastrointestinal tract, and substantially all of the phosphate is excreted in the urine, with the remainder excreted in the feces. Excessive phosphate intake, especially by intravenous, rectal administration, or in patients with renal failure, may cause hyperphosphatemia, leading to hypocalcemia or other serious electrolyte disorders. Phosphate is administered orally or rectally as a palliative salt laxative. Disodium hydrogen phosphate, as an excipient for oral preparations, may cause gastrointestinal disorders, including diarrhea, nausea, and vomiting. However, when disodium hydrogen phosphate is used as an excipient for pharmaceutical preparations, there is generally no adverse reaction.

4. Characteristic R & D service

1. National Pharmacopoeia Detection Operation Decomposition Guidance

2. Customized specialty preparation services

Key words:

phosphate

hydrogen

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