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Tromethamine hydrochloride

Classification:

Pharmaceutical excipients for biologics

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Tromethamine hydrochloride

Detailed introduction

1. Product Description

Tromethamine hydrochloride, also known as three hydroxymethyl aminomethane hydrochloride, white crystalline powder, good water solubility, soluble in methanol, ethanol insoluble, is the biological macromolecules in the stable preservation, electrophoresis and analysis of the buffer components commonly used in the experiment. It is not only widely used as a solvent for nucleic acids and proteins, but also has many important uses: Tris HCl buffer system can be used in gels to better stabilize the pH value, and it can also form a buffer system with glycine to stabilize the pH value in electrophoresis buffer. In addition, Tris hydrochloride has been gradually developed and applied to pharmaceutical products as a pharmaceutical excipient.

Product Name	English Name	CAS No.	Item No.	Packing specification	Executive standard	CDE Registration Number	FDA Registration Number
tromethamine hydrochloride	Trometamol hydrochloride	1185-53-1	F602-000500	500g/bottle	——	To be registered	——
tromethamine hydrochloride	Trometamol hydrochloride	1185-53-1	F602-001000	1kg/bottle	——	To be registered	——
tromethamine hydrochloride	Trometamol hydrochloride	1185-53-1	F602-010000	10kg/barrel	——	To be registered	——
tromethamine hydrochloride	Trometamol hydrochloride	1185-53-1	F602-025000	25kg/barrel	——	To be registered	——

2. Product advantages

Meet the needs of different regulatory market standards: CP/USP/EP/JP;

Lower impurity residue: strictly control the residue of impurities and pollutants;

Customized packaging: different sizes of packaging can be used according to customer needs;

Higher safety: strict control of microorganisms and endotoxins.

Product Name	English Name	endotoxin	Aerobic bacteria (TAMC)	Mold and Yeast (TYMC)	Escherichia coli
tromethamine hydrochloride	Trometamol hydrochloride	<2.0EU/g	<100cfu/g	<10cfu/g	None

3. Product Application

Buffer:Tromethamine is a good buffer because it has a low UV absorbance, a stable pH, and is soluble in water, and is commonly used as a buffer for vaccines and antibiotics, such as mRNA vaccines. Tris buffer is widely used in biochemical research. Its common effective pH range is in the "neutral" range, such as Tris-HCl buffer (pH = 7.5~8.5) and Tris-phosphate buffer (pH = 5.0~9.0). The advantages of Tris-HCl buffer are as follows:

1) Because of the strong alkalinity of Tris base, it is possible to use only this buffer system to prepare buffers with a wide range of pH values ranging from acidic to alkaline;

2) the biochemical process interference is very small, not with calcium, magnesium ions and heavy metal ions precipitation.

Stable pH:The Tris HCl buffer system can be used in the gel to better stabilize the pH value, and the buffer system can also be formed with glycine to stabilize the pH value in the electrophoresis buffer.

Pharmaceutical intermediates:As an organic amine, tromethamine can form a double salt easily soluble in water with insoluble drugs with acidic groups. The representative drugs include fosfomycin tromethamine, dextroketoprofen tromethamine, ketorolac tromethamine, prostaglandin tromethamine intermediates, etc.

4. Characteristic R & D service

1. National Pharmacopoeia Detection Operation Decomposition Guidance

2. Customized specialty preparation services

Key words:

hydrochloride

tromethamine

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