中文

Tromethamine

Tromethamine 1. product description tromethamine is white crystal, soluble in water, commonly used as buffer, acid-base balance regulator. Tromethamine is an important solvent for nucleic acids and proteins, a biological buffer, and an acidometric reference substance

Classification:

Pharmaceutical excipients for biologics

Telephone:

86-0711-3813176

Message

Tromethamine

Detailed introduction

1. Product Description

Tromethamine is white crystal, soluble in water, commonly used as buffer, acid-base balance regulator. Tromethamine is an important nucleic acid and protein solvent, biological buffer and acid titration reference material, widely used in the biopharmaceutical industry, such as monoclonal antibodies, recombinant proteins, insulin, etc., as well as biochemical and molecular biochemical experiments in the preparation of buffer. Tromethamine is also used as a pharmaceutical excipient for chemical injection, and its representative drugs include iopromide injection, iofanol injection and so on.

Product Name	English Name	CAS No.	Item No.	Packing specification	Executive standard	CDE Registration Number	FDA Registration Number
Tromethamine	Trometamol	77-86-1	F601-000500	500g/bottle	CP/USP/EP/JP	F20220000517	——
Tromethamine	Trometamol	77-86-1	F601-001000	1kg/bottle	CP/USP/EP/JP	F20220000517	——
Tromethamine	Trometamol	77-86-1	F601-010000	10kg/barrel	CP/USP/EP/JP	F20220000517	——
Tromethamine	Trometamol	77-86-1	F601-025000	25kg/barrel	CP/USP/EP/JP	F20220000517	——

2. Product advantages

Meet the needs of different regulatory market standards: CP/USP/EP/JP;

Lower impurity residue: strictly control the residue of impurities and pollutants;

Customized packaging: different sizes of packaging can be used according to customer needs;

Higher safety: strict control of microorganisms and endotoxins.

Product Name	English Name	endotoxin	Aerobic bacteria (TAMC)	Mold and Yeast (TYMC)	Escherichia coli
Tromethamine	Trometamol	<2.0EU/g	<100cfu/g	<10cfu/g	None

3. Product Application

BufferTromethamine is a good buffer because it has a low UV absorbance, a stable pH, and is soluble in water, and is commonly used as a buffer for vaccines and antibiotics, such as mRNA vaccines. Tris buffer is widely used in biochemical research. Its common effective pH range is in the "neutral" range, such as Tris-HCl buffer (pH = 7.5~8.5) and Tris-phosphate buffer (pH = 5.0~9.0). The advantages of Tris-HCl buffer are as follows:

1) Because of the strong alkalinity of Tris base, it is possible to use only this buffer system to prepare buffers with a wide range of pH values ranging from acidic to alkaline;

2) the biochemical process interference is very small, not with calcium, magnesium ions and heavy metal ions precipitation.

acid-base balance regulatorTromethamine can be used as an acid-base balance regulator, and tromethamine is often used as an acid-base balance regulator in eye drops.

pharmaceutical intermediatesAs an organic amine, tromethamine can form a double salt easily soluble in water with insoluble drugs with acidic groups. The representative drugs include fosfomycin tromethamine, dextroketoprofen tromethamine, ketorolac tromethamine, prostaglandin tromethamine intermediates, etc.

4. Characteristic R & D service

1. National Pharmacopoeia Detection Operation Decomposition Guidance

2. Customized specialty preparation services

Key words:

tromethamine

product

Product recommend

Sodium salicylate

Sodium dodecyl sulfate

Sorbitol Sorbitan Solution

Sorbitol

Triethanolamine