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Medium-Chain Triglycerides (for injection)
- Product description
- Product Description
- Medium-Chain Triglycerides (MCT) is a colorless to slightly yellow clear oily liquid, almost odorless. It is a triglyceride mixture obtained by esterifying saturated fatty acids such as octanoic acid (C8H16O2) and capric acid (C10H20O2) with glycerin. The total amount of octanoic acid (C8H16O2) and capric acid (C10H20O2) must not be less than 95.0%. Its fatty acids are derived from the hard dried part of the endosperm of coconut (Cocos nucifera L.) or fatty oil extracted from the dried part of the endosperm of oil palm (Elaeis guineensis Jacq).
Application Range (Purpose)- In topical formulations, it is one of the components of ointments, creams and liquid emulsions.
- In the preparation for oral administration, it can be used as the base of the preparation, as well as the small intestine absorption enhancer, the filler of capsules and sugar-coated tablets, and the lubricant and anti-adhesion agent in tablets.
- In injection preparations, it can be used as a solvent and co-solvent in the following intravenous injection products such as fat emulsions, solution and suspension injections.
- In terms of treatment, it can be used as a nutritional agent: the application of MCT and long-chain triglycerides in TPN (total nutrition infusion therapy) has been studied.
- It has been listed in GRAS and has been included in the FDA's "Inactive Ingredient Guide" in the United States. European approval for non-injectable and injectable preparations.
Product Advantages- Similar to long-chain triglycerides, but easier to absorb than long-chain triglycerides. Unlike ordinary oils, it is easily soluble in ethanol. There are no double bonds in the structure, the peroxide value is very low, the oxidation stability is good, and the influence on the stability of the active drug is avoided. Low viscosity, lower freezing point than general vegetable oil. Fewer adverse reactions than other oil solvents such as peanut oil
- Better raw materials: Use octanoic and capric acids with a purity of over 99% as raw materials to avoid impurities from other sources.
- Higher safety: Sterility, control of bacterial endotoxin, reduction of the risk of introduction of exogenous biological impurities in the production process of the preparation, and meeting the requirements of injections, ophthalmic and inhaled preparations.
- Better stability: nitrogen filling protection measures are taken during the filling process to ensure consistent quality during product storage
Precautions- In the preparation of microemulsions, self-emulsifying systems, emulsions, or aqueous suspensions, it is necessary to prevent microbial contamination to avoid MCT hydrolysis.
- Avoid contact with polystyrene containers or packaging materials to prevent them from becoming brittle quickly; some plasticizers such as phthalates can be dissolved in plastics, so polyethylene and phenol resin packaging materials should be used before Detection of compatibility with MCT.
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