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The 85th API China, Ge Dian Renfu Medicine Assistant Invites You to Meet!

10-10

Warmly congratulate our products successfully obtain DMF filing number

05-13

2019 China Bio & Chemical Pharmaceutical Technology Service Expo

From September 9th to 10th, 2019, the "2019 China Biological & Chemical Drug Technology Service Expo" co-sponsored by Pharmaceutical Finance Circle and Baiao Valley was grandly opened in the beautiful Dushu Lake in Suzhou. More than 2000 innovative drug pioneers, excellent pharmaceutical research, commissioned processing and clinical service enterprises in chemical pharmacy and biology, and elites in the pharmaceutical industry gathered in Suzhou to participate in the Expo to jointly discuss the upgrading of the pharmaceutical industry: from raw materials to preparations, from chemical drugs to biological drugs, from generic drugs to innovative drugs; To find the best technical development, consultation, clinical and

11-18

Publicity: Benzalkonium chloride (RF40)CDE registration number has been publicized

Last week, the registration number of benzalkonium chloride (RF40) of Gedian Renfu Pharmaceutical Accessories Co., Ltd. was publicized on CDE Raw and Auxiliary Package Registration Platform, with the registration number of F20190000408. Benzalkonium chloride (RF40) is also a benzalkonium chloride product launched by our company that can meet the 2020 edition of Chinese Pharmacopoeia standards. Benzalkonium chloride (Benzalkoniumchloride) chemical name is dimethyl benzyl alkyl ammonium chloride, is a quaternary ammonium compound, bacteria, yeast and fungi have a good antibacterial effect. Benzalkonium chloride, as a pharmaceutical excipient, is commonly used in eye and inhalation preparations, and is an effective antibacterial preservative. When the alkyl chain of benzalkonium chloride is different, the bactericidal effect is also different. When the alkyl chain is C12H25, benzalkonium chloride mainly kills fungi, when the alkyl chain is C14H29, benzalkonium chloride mainly kills gram-positive bacteria, and when the alkyl chain is C16H33, benzalkonium chloride benzene mainly kills gram-negative bacteria. The structural formula of benzalkonium chloride Recently, on the official website of the National Pharmacopoeia Commission, the draft of the latest quality standard for benzalkonium chloride 2020 edition pharmacopoeia was publicized. In this quality standard, the alkyl chain ratio of benzalkonium chloride is clearly required, of which n-C12H25 shall not be less than 40%,n-C14H29 shall not be less than 20%, and the total amount of both shall not be less than 70%. Therefore, according to the latest pharmacopoeia standard, Gedianrenfu medicine auxiliary has introduced benzalkonium chloride (RF40) that meets the relevant quality standards. In the draft for soliciting opinions on the quality standard for benzalkonium chloride in the 2020 edition of the Pharmacopoeia, the detection methods for related substances of benzalkonium chloride are also specified, requiring the control of benzyl alcohol, benzaldehyde and benzyl chloride in benzalkonium chloride, of which benzyl chloride is a genotoxic impurity. Through a long period of exploration, Gedian Renfu medicine auxiliary has formed a set of technology to reduce the content of related substances, which can reduce the content of benzyl alcohol and benzaldehyde to less than 0.01%, and the genotoxic impurity benzyl chloride can reach undetected, thus improving the product quality. The following table compares the quality standards of benzalkonium chloride in the 2015 and 2020 pharmacopoeia drafts. Project 2015 version 2020 version of the draft for comments this product is white waxy solid or yellow colloidal body this product is white to yellowish white powder, waxy solid or colorless to light yellow colloidal matter alkyl composition ratio of no n-C12H25 shall not be less than 40%,n-C14H29 shall not be less than 20%, the total amount of the two shall not be less than 70% related substances no benzyl alcohol ≤ 0.5; Benzaldehyde ≤ 0.15%; benzyl chloride ≤ 0.05 pH, clarification and color of solution, water insoluble matter, ammonia compound, moisture, ignition residue and content have not changed. With the approach of the 2020 Pharmacopoeia standard, Gedianrenfu Medicine Co., Ltd. has introduced benzalkonium chloride (RF40) that meets the latest quality requirements. The product has been associated with several preparations. Ge shop people welcome the majority of customers and friends to consult and understand the product. In the next few months, we will also submit research materials on benzyl benzoate (for injection), castor oil (for injection), sesame oil (for injection), peanut oil, sesame oil and other products on the CDE raw package registration platform. It is believed that the high-risk auxiliary materials products of Hubei Gedian Renfu Pharmaceutical Accessories Co., Ltd. will be more and more complete and more and more. Meet the production and R & D needs of domestic pharmaceutical companies and provide more choices for pharmaceutical companies! Link: last week's public number of ethyl paraben and butyl ester.

11-18

Ge Dian Renfu Medicine Assistant 2019 Staff Group Tour Successfully Concluded

The growth of employees is the growth of the enterprise, and the happiness of employees is the happiness of the enterprise. In order to strengthen the construction of corporate culture, reflect the company's humanized management, and implement the care of employees, let employees finish the busy work in the first half of the year, relax and enjoy the pleasant scenery of nature. With the support of the company's leaders, the company organized a trip to Guilin and Ningxia in batches during the company's annual production equipment shutdown and maintenance. Wandering between the smart and beautiful landscape, indulge in the vast desert oasis of enthusiasm. Through this collective activity, everyone not only enjoyed the beautiful scenery, relaxed their body and mind, and relieved the pressure brought by work and life.

11-18

Ge Dian Renfu Medicine Auxiliary Appears at 19th World Pharmaceutical Raw Materials China Exhibition (CPhI China 2019)

From June 18 to 20, 2019, the 19th World Pharmaceutical Raw Materials China Exhibition (CPhIChina2019) was grandly held in Shanghai New International Expo Center. As the weather vane of the international pharmaceutical industry, the CPhIChina covers all 17 pavilions of the New International Expo Center, creating the strongest lineup in history. The exhibition brought together more than 3200 outstanding domestic and foreign companies, including pavilions from South Korea, India, Poland, Turkey, Russia and other countries and more than 200 independent overseas exhibitors from the United States, Germany, France, Switzerland, Italy and other countries. Attracted from 120 countries and regions

11-18